Scientific Evidence

Extensive scientific research shows evidence of enhanced brain activity in response to personally-relevant content compared to generic content. MemoryCo™ leverages these findings to provide fun, interactive activities that support cognitive health and enable new ways of interaction among seniors. Here are a few relevant scientific articles from our founders and collaborators:
 Playing video games for four weeks can improve hippocampal-based memory in a population that is already experiencing age-related decline in memory:
 Clemenson GD, et al. (2020) Enriching hippocampal memory function in older adults through video games. Behav Brain Res. 390:112667.
 Adopting new technologies have the potential to reduce or delay cognitive changes associated with ageing:
 Vaportzis, E., Martin, M., & Gow, A. J. (2017). A tablet for healthy ageing: the effect of a tablet computer training intervention on cognitive abilities in older adults. The American Journal of Geriatric Psychiatry, 25(8), 841-851.
 Participation in cognitive activities pertinent to game playing may help prevent Alzheimer's by preserving brain structures and cognitive functions:
 Schultz, S. A., et al. (2015). Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer’s disease. Brain imaging and behavior, 9(4), 729-736.
 Being mentally active helps fend off cognitive impairments, underlining the importance of MemoryCo™ games and activities:
 Janina Krell-Roesch et al. (2019). Quantity and quality of mental activities and the risk of incident mild cognitive impairment. Neurology 93(6), e548-e558.
 The importance of personally-relevant information in memory recall:
  Renoult, L., et al. (2016). Personal semantics: Is it distinct from episodic and semantic memory? An electrophysiological study of memory for autobiographical facts and repeated events. Neuropsychologia, 83, 242-256.
 Brain activity is increased when personally-relevant images and content are shown--which is central to MemoryCo™'s approach:
 Viskontas, I. V., Quiroga, R. Q., & Fried, I. (2009). Human medial temporal lobe neurons respond preferentially to personally relevant images. Proceedings of the National Academy of Sciences, 106(50), 21329-21334.
 Personally-relevant memories are in brain regions targeted by the MemoryCo™ games and activities:
 Okuyama, T., Kitamura, T., Roy, D. S., Itohara, S., & Tonegawa, S. (2016). Ventral CA1 neurons store social memory. Science, 353(6307), 1536-1541.
 The importance of MemoryCo™'s personally-relevant content in the grand context of memory:
  Renoult, L., et al. (2012). Personal semantics: at the crossroads of semantic and episodic memory. Trends in cognitive sciences, 16(11), 550-558.
 This article is a summary from over a decade of findings highlighting the importance of personally-relevant information in memory performance:
  Suthana, N., & Fried, I. (2012). Percepts to recollections: insights from single neuron recordings in the human brain. Trends in cognitive sciences, 16(8), 427-436.
 This study shows that improving brain activity, as applied by MemoryCo™, leads to better memory performance:
 Titiz, A., Hill, M. R., Mankin, E. A., Aghajan, Z. M., Eliashiv, D., Tchemodanov, N., ... & Behnke, E. (2017). Theta-burst microstimulation in the human entorhinal area improves memory specificity. Elife, 6, e29515.
 This study shows the relationship between sleep and memory in the context of neurological disorders:
 Titiz, A., Mahoney, J. M., Testorf, M. E., Holmes, G. L., & Scott, R. C. (2014). Cognitive impairment in temporal lobe epilepsy: role of online and offline processing of single cell information. Hippocampus, 24(9), 1129-1145.
 This study shows the importance of the pacing of cognitive tasks to optimize learning:
 Richard, G. R., Titiz, A., Tyler, A., Holmes, G. L., Scott, R. C., & Lenck‐Santini, P. P. (2013). Speed modulation of hippocampal theta frequency correlates with spatial memory performance. Hippocampus, 23(12), 1269-1279.
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